Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 3054
LigandPNGBDBM27359(7-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27380((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 2nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27371(2-(2-aminopyrimidin-4-yl)-7,7-dimethyl-1H,4H,5H,6H...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27362(7-(2-fluoroethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27361(7-cyclobutyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27348(6-(2-methylpropyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27363(7,7-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27370(2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27368(2-(2-aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H...)
Affinity DataIC50: 4nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27377(2-(2-aminopyrimidin-4-yl)-7-(2-hydroxyethyl)-1H,4H...)
Affinity DataIC50: 4nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27367(2-(2-aminopyrimidin-4-yl)-7-ethyl-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27369(2-(2-aminopyrimidin-4-yl)-7-cyclobutyl-1H,4H,5H,6H...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27379((7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 5nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27347(6-cyclopropyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrr...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27372(2-(2-aminopyrimidin-4-yl)-7,7-diethyl-1H,4H,5H,6H,...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27364(7,7-diethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrol...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27366(2-(2-aminopyrimidin-4-yl)-7-methyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27346(6-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27375(2-(2-aminopyrimidin-4-yl)-7-[2-(benzyloxy)ethyl]-1...)
Affinity DataIC50: 7nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27351(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 7nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27355(2-(2-aminopyrimidin-4-yl)-6-(2-methylpropyl)-1H,4H...)
Affinity DataIC50: 8nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27358(7-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27374(2-(2-aminopyrimidin-4-yl)-7-(3,3,3-trifluoropropyl...)
Affinity DataIC50: 10nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27360(7-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27354(2-(2-aminopyrimidin-4-yl)-6-cyclopropyl-1H,4H,5H,6...)
Affinity DataIC50: 11nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27353(2-(2-aminopyrimidin-4-yl)-6-(propan-2-yl)-1H,4H,5H...)
Affinity DataIC50: 12nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27378(2-(2-aminopyrimidin-4-yl)-7-(3-hydroxypropyl)-1H,4...)
Affinity DataIC50: 12nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27345(6-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 13nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27373(2-(2-aminopyrimidin-4-yl)-7-phenyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 19nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27365(7-phenyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 20nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27376(2-(2-aminopyrimidin-4-yl)-7-[3-(benzyloxy)propyl]-...)
Affinity DataIC50: 24nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27352(2-(2-aminopyrimidin-4-yl)-6-methyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 26nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Nerviano Medical Sciences

LigandPNGBDBM27380((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 28nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27349(6,6-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50: 32nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27350(6-[(benzyloxy)methyl]-2-(pyridin-4-yl)-1H,4H,5H,6H...)
Affinity DataIC50: 44nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27357(2-(2-aminopyrimidin-4-yl)-6-[(benzyloxy)methyl]-1H...)
Affinity DataIC50: 52nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27356(2-(2-aminopyrimidin-4-yl)-6,6-dimethyl-1H,4H,5H,6H...)
Affinity DataIC50: 64nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Nerviano Medical Sciences

LigandPNGBDBM27379((7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 96nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed