Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50028025
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255472((S)-1-oxo-3-phenyl-2-(pyridin-2-yl)-N-(4-(trifluor...)
Affinity DataIC50: 8.5nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255380((S)-N-(4-tert-butylphenyl)-1-oxo-2,3-diphenyl-2,7-...)
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255380((S)-N-(4-tert-butylphenyl)-1-oxo-2,3-diphenyl-2,7-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255472((S)-1-oxo-3-phenyl-2-(pyridin-2-yl)-N-(4-(trifluor...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255382((S)-N-((1r,4S)-4-tert-butylcyclohexyl)-1-oxo-2,3-d...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255521((S)-N-(4-isopropylphenyl)-1-oxo-2,3-diphenyl-2,7-d...)
Affinity DataIC50: 43nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255382((S)-N-((1r,4S)-4-tert-butylcyclohexyl)-1-oxo-2,3-d...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255471(N-(4-tert-butylphenyl)-1-oxo-2-phenyl-2,7-diazaspi...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255471(N-(4-tert-butylphenyl)-1-oxo-2-phenyl-2,7-diazaspi...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255521((S)-N-(4-isopropylphenyl)-1-oxo-2,3-diphenyl-2,7-d...)
Affinity DataIC50: 81nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255428(rac-1-oxo-2,3-diphenyl-N-(4-(trifluoromethyl)pheny...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255381(N-(4-isopropylphenyl)-1-oxo-2,3-diphenyl-2,7-diaza...)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255428(rac-1-oxo-2,3-diphenyl-N-(4-(trifluoromethyl)pheny...)
Affinity DataIC50: 103nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255381(N-(4-isopropylphenyl)-1-oxo-2,3-diphenyl-2,7-diaza...)
Affinity DataIC50: 113nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255429(rac-1-oxo-2,3-diphenyl-N-(6-(trifluoromethyl)pyrid...)
Affinity DataIC50: 205nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255427((S)-1-oxo-2,3-diphenyl-N-(4-(2-phenylpropan-2-yl)p...)
Affinity DataIC50: 226nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255426((S)-N-((1s,4R)-4-tert-butylcyclohexyl)-1-oxo-2,3-d...)
Affinity DataIC50: 232nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255429(rac-1-oxo-2,3-diphenyl-N-(6-(trifluoromethyl)pyrid...)
Affinity DataIC50: 318nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of PMA-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50255426((S)-N-((1s,4R)-4-tert-butylcyclohexyl)-1-oxo-2,3-d...)
Affinity DataIC50: 528nMAssay Description:Antagonist activity at TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced activation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed