Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50027818
TargetProstaglandin G/H synthase 2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50266017(5-(3,5-di-tert-butyl-4-hydroxyphenyl)-3H-1,2-dithi...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50266016(5-(3,5-di-tert-butyl-4-methoxyphenyl)-3H-1,2-dithi...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50266017(5-(3,5-di-tert-butyl-4-hydroxyphenyl)-3H-1,2-dithi...)
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50266016(5-(3,5-di-tert-butyl-4-methoxyphenyl)-3H-1,2-dithi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed