Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50032681
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 790nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as 8-hydroxyefavirenz 14-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using 8-hydroxyefavirenz as probe after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as Tolbutamide 4'-hydroxylation after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as probe after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin 4'-hydroxylation after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of CYP2C9 using Tolbutamide as probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP2C19 using S-mephenytoin as probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of human CYP2B6 expressed in baculovirus assessed as voriconazole N-oxide formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using efavirenz as probe after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  340nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  400nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as Tolbutamide 4-methylhydroxylation after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin 4'-hydroxylation after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed