Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50027334
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274635((3-((6-amino-8-mercapto-2-(2-methoxyethoxy)-9H-pur...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at TLR7 in human PBMC cells assessed as stimulation of interferon releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274598((3-((6-amino-2-(benzylamino)-8-hydroxy-9H-purin-9-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at TLR7 in human PBMC cells assessed as stimulation of interferon releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274598((3-((6-amino-2-(benzylamino)-8-hydroxy-9H-purin-9-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274596(6-amino-9-benzyl-N-(2-methoxyethyl)-8-oxo-8,9-dihy...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50241081(9-benzyl-8-hydrazinyl-2-(2-methoxyethoxy)-9H-purin...)
Affinity DataEC50:  790nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189512(3-(6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189513(9-benzyl-N8-ethyl-2-(2-methoxyethoxy)-9H-purine-6,...)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50189514(9-benzyl-2-(2-methoxyethoxy)-9H-purine-6,8-diamine...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274597(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(thiazo...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274635((3-((6-amino-8-mercapto-2-(2-methoxyethoxy)-9H-pur...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TLR7 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274760(E5564 | 3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at TLR4 in human HL60 cells assessed as inhibition of LPS-induced cytokine productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274760(E5564 | 3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177125(ethyl 6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cycl...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274714(2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholi...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NF-kappaB lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274715(N-(2-(dimethylamino)ethyl)-2-(4-(4-methylpiperazin...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NF-kappaB lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177145(ethyl 5-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cycl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177119(ethyl 6-[N-(4-chloro-2-fluorophenyl)sulfamoyl]cycl...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274716(Dodecanoic acid 3-{(S)-2-hexadecanoylamino-3-[hydr...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274718(Phosphoric acid 2-{(2S,3S)-2-[2-(5-benzyloxy-1H-in...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177129(7-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohept-1-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274717(Phosphoric acid (S)-2-(3-hydroxy-hexadecylcarbamoy...)
Affinity DataIC50: 460nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274719(Dodecanoic acid 1-(2-{(S)-3-[(2-{(2S,3R)-3-carboxy...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274678(N,N-dimethyl-2-(2-(4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NF-kappaB lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50241033(N-[(1R)-2-{[(2R)-2-{[(1S)-1-{[(1S)-5-amino-1-{[(1S...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TLR2-mediated IL8 secretion in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274677(N'-(2-Biphenyl-4-yl-quinazolin-4-yl)-N,N-dimethyl-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as blockade of CpG oligonucleotide-induced immune response by NF-kappaB lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177128(ethyl 2-[N-(2-chloro-4-fluorophenyl)sulfamoyl]benz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274759(6-(4,5-Dihydro-thiazol-2-ylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed