Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50027069
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 0.540nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofu...)
Affinity DataIC50: 0.720nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263357(trans-7'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 3.60nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263325(trans-6'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263321(N-methyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-3H-spir...)
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264067(N-methyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-2,3-dih...)
Affinity DataIC50: 43nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264069(N,2-dimethyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-2,3...)
Affinity DataIC50: 45nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264068(N-methyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-2,3-dih...)
Affinity DataIC50: 53nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264066(N-methyl-4-oxo-N-[2-(piperidin-1-yl)ethyl]-3,4-dih...)
Affinity DataIC50: 68nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263900(N-methyl-4,4-diphenyl-N-(2-(piperidin-1-yl)ethyl)p...)
Affinity DataIC50: 98nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263844(N-methyl-4-(naphthalen-2-yl)-N-(2-(piperidin-1-yl)...)
Affinity DataIC50: 110nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264012(4-(4-chlorophenyl)-N-methyl-N-(2-(piperidin-1-yl)e...)
Affinity DataIC50: 160nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263898(4-benzoyl-N-methyl-N-(2-(piperidin-1-yl)ethyl)pipe...)
Affinity DataIC50: 237nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263948(4-cyano-N-methyl-4-phenyl-N-(2-(piperidin-1-yl)eth...)
Affinity DataIC50: 267nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263952(4-(3-chlorophenyl)-N-methyl-N-(2-(piperidin-1-yl)e...)
Affinity DataIC50: 297nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263845(N-methyl-4-(naphthalen-1-yl)-N-(2-(piperidin-1-yl)...)
Affinity DataIC50: 343nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264065(N-methyl-1-oxo-N-[2-(piperidin-1-yl)ethyl]-1,4-dih...)
Affinity DataIC50: 380nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263322(N-methyl-N-[2-(piperidin-1-yl)ethyl]-3H-spiro[2-be...)
Affinity DataIC50: 387nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263897(4-benzyl-N-methyl-N-(2-(piperidin-1-yl)ethyl)piper...)
Affinity DataIC50: 393nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263950(N-methyl-4-phenyl-N-(2-(piperidin-1-yl)ethyl)piper...)
Affinity DataIC50: 506nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263899(N-methyl-N-[2-(piperidin-1-yl)ethyl]-1,3-dihydrosp...)
Affinity DataIC50: 530nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264016(N-methyl-4'-oxo-N-[2-(piperidin-1-yl)ethyl]-3',4'-...)
Affinity DataIC50: 560nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263896(N-methyl-N-(2-(piperidin-1-yl)ethyl)-3,4-dihydrois...)
Affinity DataIC50: 680nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264014(3-Oxo-3,4-dihydro-2H-spiro[isoquinoline-1,4'-piper...)
Affinity DataIC50: 783nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263846(N-methyl-4-phenyl-N-(2-(piperidin-1-yl)ethyl)piper...)
Affinity DataIC50: 893nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264015(N-methyl-2-oxo-N-[2-(piperidin-1-yl)ethyl]-1,2-dih...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264013(4-tert-butyl-N-methyl-N-(2-(piperidin-1-yl)ethyl)p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263949(4-hydroxy-N-methyl-4-phenyl-N-(2-(piperidin-1-yl)e...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263951(4-(2-chlorophenyl)-N-methyl-N-(2-(piperidin-1-yl)e...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(trans-3'-Oxo-3'H-spiro[cyclohexane-1,1'-isobenzofu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed