Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50026888
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244684(N-(4-(ethylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244588(1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrim...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244589(1-[6-(4-Methanesulfonyl-phenylamino)-5-nitro-pyrim...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244590(1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenylamino)-p...)
Affinity DataEC50:  400nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244441(1-{6-[4-(2-Methoxycarbonyl-acetyl)-phenoxy]-5-nitr...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244637({6-[4-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244638((4-Methanesulfonyl-phenyl)-{5-nitro-6-[4-(3-propyl...)
Affinity DataEC50:  430nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244639({6-[4-(3-Cyclopropyl-[1,2,4]oxadiazol-5-yl)-piperi...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244640(6-[4-(3-Cyclopropylmethyl-[1,2,4]oxadiazol-5-yl)-p...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244680({6-[4-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-piperidi...)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244681({6-[4-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-piperid...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244682(N-(4-(methylsulfonyl)phenyl)-5-nitro-6-(4-(3-(pyri...)
Affinity DataEC50:  660nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244683((4-Methanesulfonyl-phenyl)-(5-nitro-6-{4-[3-(3-tri...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244539(1-[5-Nitro-6-(4-sulfamoyl-phenoxy)-pyrimidin-4-yl]...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244732(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244733(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Affinity DataEC50:  7.80nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244734(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Affinity DataEC50:  17.1nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244735(N-(4-(ethylthio)phenyl)-6-(4-(3-isopropyl-1,2,4-ox...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244790((3-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244791((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244792(N-ethyl-3-fluoro-4-(6-(4-(3-isopropyl-1,2,4-oxadia...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244793(3-fluoro-N-isopropyl-4-(6-(4-(3-isopropyl-1,2,4-ox...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244591((4-Methanesulfonyl-phenyl)-{6-[4-(3-methyl-[1,2,4]...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244536(1-{5-Nitro-6-[4-(3-oxo-butyl)-phenoxy]-pyrimidin-4...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244538(1-[6-(4-Methanesulfonyl-phenoxy)-5-nitro-pyrimidin...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244398(1-[6-(4-bromo-phenoxy)-5-nitro-pyrimidin-4-yl]-pip...)
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244851(ethyl 1-(6-(1-methyl-3-(trifluoromethyl)-1H-pyrazo...)
Affinity DataIC50: 84nMAssay Description:Inverse agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244537(ethyl 1-(6-(4-(2-methoxyethoxy)phenoxy)-5-nitropyr...)
Affinity DataIC50: 500nMAssay Description:Inverse agonist activity at GPR119 expressed in HEK293 cells assessed as cAMP level by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed