Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50026759
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132140(1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...)
Affinity DataEC50:  860nMAssay Description:Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132140(1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...)
Affinity DataEC50:  500nMAssay Description:Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  1.65E+3nMAssay Description:Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216525(6-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216525(6-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  1.22E+4nMAssay Description:Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity against human GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  400nMAssay Description:Agonist activity against mouse GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity against rat GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132140(1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...)
Affinity DataEC50:  1.04E+4nMAssay Description:Agonist activity against human GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23515(pyridine-3-carboxylic acid | CHEMBL573 | [5, 6-3H]...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed