Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50026632
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262471((R)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262466((S)-N-(2,3,4-trichlorobenzyl)-N-(pyrrolidin-3-yl)i...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50203945((S)-N-(2,3-dimethylbenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203945((S)-N-(2,3-dimethylbenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262411((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262303((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262415(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-isobut...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262466((S)-N-(2,3,4-trichlorobenzyl)-N-(pyrrolidin-3-yl)i...)
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262412((S)-N-(2,3-dichlorobenzyl)-3-methyl-N-(pyrrolidin-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262411((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262468((S)-N-(2-fluoro-4-(trifluoromethyl)benzyl)-N-(pyrr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262363((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)cycl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262300((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)prop...)
Affinity DataIC50: 25nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262413((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)piva...)
Affinity DataIC50: 26nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262362((S)-N-(2,4-dichlorobenzyl)-3,3-dimethyl-N-(pyrroli...)
Affinity DataIC50: 27nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262303((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262467((S)-N-(2,3,5-trichlorobenzyl)-N-(pyrrolidin-3-yl)i...)
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262360((S)-N-(2,4-dichlorobenzyl)-3-methyl-N-(pyrrolidin-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262301((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)buty...)
Affinity DataIC50: 31nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262302((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)pent...)
Affinity DataIC50: 33nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262471((R)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 37nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262363((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)cycl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262362((S)-N-(2,4-dichlorobenzyl)-3,3-dimethyl-N-(pyrroli...)
Affinity DataIC50: 39nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262361((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)piva...)
Affinity DataIC50: 41nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262364((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)cycl...)
Affinity DataIC50: 41nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262467((S)-N-(2,3,5-trichlorobenzyl)-N-(pyrrolidin-3-yl)i...)
Affinity DataIC50: 44nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262300((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)prop...)
Affinity DataIC50: 60nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262412((S)-N-(2,3-dichlorobenzyl)-3-methyl-N-(pyrrolidin-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262364((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)cycl...)
Affinity DataIC50: 64nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262302((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)pent...)
Affinity DataIC50: 70nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262301((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)buty...)
Affinity DataIC50: 72nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262416((S)-N-(2-chlorobenzyl)-N-(pyrrolidin-3-yl)isobutyr...)
Affinity DataIC50: 91nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262361((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)piva...)
Affinity DataIC50: 92nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262360((S)-N-(2,4-dichlorobenzyl)-3-methyl-N-(pyrrolidin-...)
Affinity DataIC50: 93nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262365((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)benz...)
Affinity DataIC50: 94nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262469((S)-N-(2-chloro-4-fluorobenzyl)-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 98nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262416((S)-N-(2-chlorobenzyl)-N-(pyrrolidin-3-yl)isobutyr...)
Affinity DataIC50: 114nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262414((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)-tet...)
Affinity DataIC50: 123nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262469((S)-N-(2-chloro-4-fluorobenzyl)-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 161nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262365((S)-N-(2,4-dichlorobenzyl)-N-(pyrrolidin-3-yl)benz...)
Affinity DataIC50: 195nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262414((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)-tet...)
Affinity DataIC50: 300nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262413((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)piva...)
Affinity DataIC50: 322nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262470((S)-N-(2,4-difluorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262468((S)-N-(2-fluoro-4-(trifluoromethyl)benzyl)-N-(pyrr...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262470((S)-N-(2,4-difluorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]NA reuptake in human noradrenaline transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262415(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-isobut...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203945((S)-N-(2,3-dimethylbenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 727nMAssay Description:Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262471((R)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262411((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262466((S)-N-(2,3,4-trichlorobenzyl)-N-(pyrrolidin-3-yl)i...)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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