Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50038632
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human alpha4beta2 nAChR expressed in human SHEP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.00900nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.0110nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.0150nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.0190nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.0210nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0250nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.0580nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0610nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.0930nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0950nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  1.33nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  1.44nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  3.02nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+/-)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  181nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50263094((S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine...)
Affinity DataKi:  3.68E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed