Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50026399
TargetTryptophan 5-hydroxylase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  750nMAssay Description:Inhibition of TPH2 in human BON cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataEC50:  560nMAssay Description:Inhibition of TPH2 in human BON cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243023((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243024((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Affinity DataEC50:  510nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataEC50:  56nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  48nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  70nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataEC50:  63nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Rat)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243022((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataEC50:  1.19E+3nMAssay Description:Inhibition of TPH2 in human BON cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataEC50:  800nMAssay Description:Inhibition of TPH2 in human BON cells assessed as inhibition of serotonin biosynthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243565((S)-2-amino-3-(4-(5-(naphthalen-2-ylmethylamino)py...)
Affinity DataIC50: 13nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataIC50: 24nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243613((S)-2-amino-3-(4-(4-amino-6-(naphthalen-2-ylmethyl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243020((S)-2-amino-3-(4-(4-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50: 26nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243619((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Affinity DataIC50: 29nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242929((S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)met...)
Affinity DataIC50: 31nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243022((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50: 32nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243019((S)-2-amino-3-(4-(5-((2'-methylbiphenyl-2-yl)methy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243018((S)-2-Amino-3-(4-{5-[(biphenyl-4-ylmethyl)-amino]-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242928((S)-2-amino-3-{4-[5-(3-cyclopentyloxy-4-methoxy-be...)
Affinity DataIC50: 45nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243564((2S)-2-amino-3-(4-(5-((1,2,3,4-tetrahydronaphthale...)
Affinity DataIC50: 46nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243655((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Affinity DataIC50: 54nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242930((S)-2-amino-3-(4-(5-(3,4-dimethoxybenzylamino)pyra...)
Affinity DataIC50: 69nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243617((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Affinity DataIC50: 70nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243507((S)-2-amino-3-(4-(5-(4-cyanobenzylamino)pyrazin-2-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243024((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Affinity DataIC50: 180nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243563((S)-2-amino-3-(4-{5-[(quinolin-3-ylmethyl)-amino]-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243021(2-Amino-3-(4-(4-amino-6-(R)-1-(naphthalene-2-yl)et...)
Affinity DataIC50: 200nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243505((S)-2-amino-3-(4-(5-(cyclohexylmethylamino)pyrazin...)
Affinity DataIC50: 240nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243023((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50: 380nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243568((S)-2-amino-3-(1-(4-amino-6-((R)-1-(naphthalen-2-y...)
Affinity DataIC50: 770nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243567((S)-2-amino-3-(5-(4-amino-6-((R)-1-(naphthalen-1-y...)
Affinity DataIC50: 890nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243506((S)-2-amino-3-(4-(5-(furan-3-ylmethyl amino)pyrazi...)
Affinity DataIC50: 960nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242932((S)-2-amino-3-(4-(6-(3-(cyclopentyloxy)-4-methoxyb...)
Affinity DataIC50: 970nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243615(3-amino-3-(4-(4-amino-6-((S)-1-naphthalen-2-yl)eth...)
Affinity DataIC50: 3.77E+3nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243562((S)-2-amino-3-(4-(5-(pyridine-2-ylmethylamino)pyra...)
Affinity DataIC50: 6.15E+3nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243616((S)-2-amino-3-(4'-(3-(cyclopentyloxy)-4-methoxy be...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50242933((S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243566(2-amino-3-(4(4-amino-6-(R)-1-(naphthalene-2-yl)eth...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243614(2-amino-3-(4-(4-amino-6-(R)-1-(naphthalene-2-yl)et...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243569((S)-2-amino-3-(3-(4-amino-6-((R)-1-(naphthalen-1-y...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of TPH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed