Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 2870
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 43nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25616(N-{4-[(6-{[3-(1,3-oxazol-5-yl)phenyl]amino}pyrazin...)
Affinity DataIC50: 310nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25612(N-[5-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 410nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25613(N-[4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 560nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25614(N-{5-[(6-{[3-(1,3-oxazol-5-yl)phenyl]amino}pyrazin...)
Affinity DataIC50: 650nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25570(4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}b...)
Affinity DataIC50: 1.10E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25569(1-phenyl-3-(4-{6-[(3,4,5-trimethoxyphenyl)amino]py...)
Affinity DataIC50: 1.20E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25580(6-(naphthalen-1-yloxy)-N-(3,4,5-trimethoxyphenyl)p...)
Affinity DataIC50: 1.20E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25609(6-{[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-4-y...)
Affinity DataIC50: 1.40E+3nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25590(6-(quinolin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 1.50E+3nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25615(N-[5-({6-[(3-oxo-1,3-dihydro-2-benzofuran-5-yl)ami...)
Affinity DataIC50: 2.50E+3nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25562(6-(pyridin-4-yl)-N-(3,4,5-trimethoxyphenyl)pyrazin...)
Affinity DataIC50: 2.90E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25568(4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}b...)
Affinity DataIC50: 3.00E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25561(N-(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-y...)
Affinity DataIC50: 3.50E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25593(6-(isoquinolin-5-yloxy)-N-(3,4,5-trimethoxyphenyl)...)
Affinity DataIC50: 3.80E+3nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25564(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}p...)
Affinity DataIC50: 4.00E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25575(2-N-(pyridin-4-yl)-6-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 4.70E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25577(4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 4.90E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25604(N-[4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 5.50E+3nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25587(6-(1H-indol-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 7.40E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25588(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}b...)
Affinity DataIC50: 9.80E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25585(6-(naphthalen-1-ylsulfanyl)-N-(3,4,5-trimethoxyphe...)
Affinity DataIC50: 9.80E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25591(6-(quinolin-5-yloxy)-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25599(6-(2-phenylphenoxy)-N-(3,4,5-trimethoxyphenyl)pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25607(6-{3-[(1Z)-1-(hydroxyimino)ethyl]phenoxy}-N-(3,4,5...)
Affinity DataIC50: 1.10E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25578(2-N-(3-fluorophenyl)-6-N-(3,4,5-trimethoxyphenyl)p...)
Affinity DataIC50: 1.20E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25603(N-[3-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 1.30E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25567(ethyl 3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-...)
Affinity DataIC50: 1.40E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25576(N-[3-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 1.40E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25574(2-N-phenyl-6-N-(3,4,5-trimethoxyphenyl)pyrazine-2,...)
Affinity DataIC50: 1.60E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25583(6-(pyridin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyra...)
Affinity DataIC50: 1.60E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25573(N-[4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 1.60E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25596(4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 1.80E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25565(4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}p...)
Affinity DataIC50: 1.80E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25586(6-(5,6,7,8-tetrahydronaphthalen-1-yloxy)-N-(3,4,5-...)
Affinity DataIC50: 1.80E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25579(2-N-(4-fluorophenyl)-6-N-(3,4,5-trimethoxyphenyl)p...)
Affinity DataIC50: 1.90E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25605(1-[3-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 1.90E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25563(6-(pyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)pyrazin...)
Affinity DataIC50: 2.20E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25598(6-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 2.20E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25566((4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 2.60E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25572(N-(3-{5-[(3,4,5-trimethoxyphenyl)amino]pyridin-3-y...)
Affinity DataIC50: 2.60E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25608(6-{4-[(1E)-1-(hydroxyimino)ethyl]phenoxy}-N-(3,4,5...)
Affinity DataIC50: 2.60E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25592(6-(quinolin-6-yloxy)-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 2.90E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25594(5-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 2.90E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25582(6-phenoxy-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amin...)
Affinity DataIC50: 3.10E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25606(1-[4-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-...)
Affinity DataIC50: 3.40E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25602(6-(3-chlorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyra...)
Affinity DataIC50: 3.60E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25589(7-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 4.40E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25584(6-(pyridin-3-yloxy)-N-(3,4,5-trimethoxyphenyl)pyra...)
Affinity DataIC50: 4.50E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25600(6-(2-fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyra...)
Affinity DataIC50: 4.50E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
Displayed 1 to 50 (of 57 total ) | Next | Last >>
Jump to: