Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 2972
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26506(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26512(BMCL193669 Compound 28 | 3-ethyl-N-[(2S,3R)-3-hydr...)
Affinity DataIC50: 15nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26510(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 30nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26504(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 34nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 59nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26509(N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 69nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26506(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 114nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 120nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26511(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 120nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26513(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 140nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)
Affinity DataIC50: 210nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26510(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 263nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)
Affinity DataIC50: 660nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26506(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 1.26E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26512(BMCL193669 Compound 28 | 3-ethyl-N-[(2S,3R)-3-hydr...)
Affinity DataIC50: 1.26E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 1.43E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26509(N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 2.34E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26504(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 3.02E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 3.90E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26509(N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 4.37E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 5.25E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26510(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 7.93E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50: 7.94E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26504(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 1.72E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26511(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 1.95E+4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 2.63E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26511(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 3.02E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 3.24E+4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26513(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 4.79E+4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26512(BMCL193669 Compound 28 | 3-ethyl-N-[(2S,3R)-3-hydr...)
Affinity DataIC50: 5.89E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26513(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed