Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50025982
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50067485(CHEMBL544440 | 3-[(Benzyl-methyl-amino)-methyl]-7-...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213665((S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)pr...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity at rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50098391(4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5...)
Affinity DataIC50: 1nMAssay Description:Activity at human GnRH receptor by inositol phosphate functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50213665((S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)pr...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244213(5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity at human GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50104552((S)-1-(2-aza-bicyclo[2.2.2]octan-2-yl)-2-(2-(3,5-d...)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity at rat GnRH receptor by whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50067485(CHEMBL544440 | 3-[(Benzyl-methyl-amino)-methyl]-7-...)
Affinity DataIC50: 4nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261183(2-(4-tert-butylphenyl)-4-(4-((2-(methylsulfonyl)py...)
Affinity DataIC50: 5.20nMAssay Description:Binding affinity at human GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261251(2-(4-tert-butylphenyl)-4-(4-((2-ethyl-4-methyl-1H-...)
Affinity DataIC50: 6.60nMAssay Description:Binding affinity at human GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50098391(4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5...)
Affinity DataIC50: 7nMAssay Description:Activity at rhesus monkey GnRH receptor by inositol phosphate functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244213(5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50: 18nMAssay Description:Binding affinity at rat GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50067485(CHEMBL544440 | 3-[(Benzyl-methyl-amino)-methyl]-7-...)
Affinity DataIC50: 60nMAssay Description:Binding affinity at rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50160488(1-Benzyl-2-(2-pyridin-3-yl-ethylsulfanyl)-1H-benzo...)
Affinity DataIC50: 120nMAssay Description:Binding affinity at human GnRH receptor by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50: 800nMAssay Description:Binding affinity at human GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261209(N-(2-methoxybenzyl)-1-benzyl-2-(ethylthio)-1H-benz...)
Affinity DataIC50: 3.40E+3nMAssay Description:Binding affinity at human GnRH receptor by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261249(N-(2-(ethylthio)-1-isopropyl-1H-benzo[d]imidazol-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity at human GnRH receptor by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261250(1-(2-(2-methoxy-5-nitrobenzylthio)-7-(hydroxy(meth...)
Affinity DataIC50: 4.10E+4nMAssay Description:Binding affinity at human GnRH receptor by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261242((R)-1-(2-fluoro-6-(methylsulfonyl)benzyl)-3-(2-ami...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166441(3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-chloro-3-metho...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50098391(4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261243((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007(3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50423641(A-198401 | CHEMBL303274)
Affinity DataKi:  0.631nMAssay Description:Binding affinity at rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166450((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162008((R)-1-(2-chloro-6-fluorobenzyl)-3-(2-amino-2-pheny...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140110((R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyph...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152714(3-((R)-2-Amino-2-phenyl-ethyl)-5-(5-chloro-thiophe...)
Affinity DataKi:  2nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261181((R)-2-(2-fluoro-6-(trifluoromethyl)benzyl)-4-(2-am...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50161500(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007(3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140111((R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylam...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261184(5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphth...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity at rat GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261241(1-(2-fluoro-6-(methylsulfinyl)benzyl)-3-((R)-2-ami...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261245(6-((R)-2-amino-2-phenylethyl)-8-(2-chloro-3-methox...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132724(1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-met...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50127199(8-(2-fluorobenzyl)-2-tert-butyl-6-(3-methoxyphenyl...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166436(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132726((R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-m...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50161999(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...)
Affinity DataKi:  6nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50116222(2-(4-Butyrylamino-phenyl)-8-(2-fluoro-benzyl)-3-{[...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149254((S)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyph...)
Affinity DataKi:  8.10nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168697(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2,6-difluoro-ben...)
Affinity DataKi:  9nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261248((R)-2-(2-fluoro-6-(trifluoromethyl)benzyl)-4-(2-am...)
Affinity DataKi:  13nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261240((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  14nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50215223(1-(2,6-difluorobenzyl)-6-(4-(methylthio)benzyl)-3-...)
Affinity DataKi:  15nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50132729((R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-m...)
Affinity DataKi:  15nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162040(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-benzyl)...)
Affinity DataKi:  19nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261182(1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylpropyl)-...)
Affinity DataKi:  23nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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