Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50025878
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179201(5'-O-{9-[3',17'beta-dihydroxy-1',3',5'(10')-estrat...)
Affinity DataIC50: 8nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179201(5'-O-{9-[3',17'beta-dihydroxy-1',3',5'(10')-estrat...)
Affinity DataIC50: 52nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179198(5'-O-{8-[3',17'beta-dihydroxy-1',3',5'(10')-estrat...)
Affinity DataIC50: 93nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179200(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 120nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179194(5'-O-{10-[3',17'beta-dihydroxy-1',3',5'(10')-estra...)
Affinity DataIC50: 140nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179195(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 310nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179197(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 430nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 600nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataIC50: 810nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM50179202(5'-O-{12-[3',17'beta-dihydroxy-1',3',5'(10')-estra...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandPNGBDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataKi:  3nMAssay Description:Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)