Compile Data Set for Download or QSAR
Report error Found 129 Enz. Inhib. hit(s) with all data for entry = 2959
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM14949(3-(2-aminoquinazolin-6-yl)-4-methyl-N-[3-(trifluor...)
Affinity DataIC50: 0.200nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26381(1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26367(N-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-3-(t...)
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26369(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26372(2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM26379(1-N-benzene-4-methyl-3-N-(2-{[4-(4-methylpiperazin...)
Affinity DataIC50: 0.900nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26367(N-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-3-(t...)
Affinity DataIC50: 1nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26383(2,2-difluoro-N-{4-methyl-3-[(2-{[4-(4-methylpipera...)
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26385(1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...)
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26384(1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...)
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14949(3-(2-aminoquinazolin-6-yl)-4-methyl-N-[3-(trifluor...)
Affinity DataIC50: 2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14949(3-(2-aminoquinazolin-6-yl)-4-methyl-N-[3-(trifluor...)
Affinity DataIC50: 2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26372(2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...)
Affinity DataIC50: 2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26381(1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...)
Affinity DataIC50: 3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26385(1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...)
Affinity DataIC50: 4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26379(1-N-benzene-4-methyl-3-N-(2-{[4-(4-methylpiperazin...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26380(1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26369(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26376(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)
Affinity DataIC50: 5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26388(2,4-dimethyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26367(N-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-3-(t...)
Affinity DataIC50: 6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14949(3-(2-aminoquinazolin-6-yl)-4-methyl-N-[3-(trifluor...)
Affinity DataIC50: 6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26375(4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...)
Affinity DataIC50: 6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26370(3-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-1-[3...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26380(1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...)
Affinity DataIC50: 8nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26389(2,6-dichloro-N-(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26374(4-methyl-3-N-(2-{[3-(morpholin-4-yl)propyl]amino}p...)
Affinity DataIC50: 10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26383(2,2-difluoro-N-{4-methyl-3-[(2-{[4-(4-methylpipera...)
Affinity DataIC50: 10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 12nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 13nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26378(5-methyl-N-{4-methyl-3-[(2-{[4-(4-methylpiperazin-...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 14nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26381(1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...)
Affinity DataIC50: 17nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14949(3-(2-aminoquinazolin-6-yl)-4-methyl-N-[3-(trifluor...)
Affinity DataIC50: 20nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26367(N-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-3-(t...)
Affinity DataIC50: 21nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26384(1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...)
Affinity DataIC50: 22nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26374(4-methyl-3-N-(2-{[3-(morpholin-4-yl)propyl]amino}p...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26369(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 24nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26370(3-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-1-[3...)
Affinity DataIC50: 28nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26384(1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...)
Affinity DataIC50: 32nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26372(2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...)
Affinity DataIC50: 41nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
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