Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 3361
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 0.220nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31826(CHEMBL188762 | BMC163482 Compound 3 | 4-aminoquina...)
Affinity DataIC50: 0.430nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 3.60nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 236nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 260nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31826(CHEMBL188762 | BMC163482 Compound 3 | 4-aminoquina...)
Affinity DataIC50: 360nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 990nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.81E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 5.71E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31826(CHEMBL188762 | BMC163482 Compound 3 | 4-aminoquina...)
Affinity DataIC50: 6.40E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1.50E+4nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Chicken)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31826(CHEMBL188762 | BMC163482 Compound 3 | 4-aminoquina...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMed