Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 2953
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26303(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26304(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26305(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26306(2-{4-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26307(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26308(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26303(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi:  340nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26304(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi:  540nM ΔG°:  -35.4kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26306(2-{4-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  1.10E+3nM ΔG°:  -33.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26305(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi:  1.30E+3nM ΔG°:  -33.3kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26307(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi:  3.00E+3nM ΔG°:  -31.2kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2009
Entry Details Article
PubMed