Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2504
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21337(6-Azido-uridine 5-O-Monophosphate | {[(2R,3S,4R,5R...)
Affinity DataKi:  190nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21338(JMC521648 Compound 37 | 6-Amino-uridine 5-O-Monoph...)
Affinity DataKi:  840nM ΔG°:  -38.2kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21340({[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,...)
Affinity DataKi:  1.10E+3nM ΔG°:  -35.4kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21337(6-Azido-uridine 5-O-Monophosphate | {[(2R,3S,4R,5R...)
Affinity DataKi:  2.00E+3nM ΔG°:  -33.8kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21338(JMC521648 Compound 37 | 6-Amino-uridine 5-O-Monoph...)
Affinity DataKi:  2.10E+3nM ΔG°:  -33.7kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21340({[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,...)
Affinity DataKi:  1.24E+4nM ΔG°:  -30.8kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(Plasmodium vivax)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  2.24E+4nMpH: 7.5Assay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21335(JMC521648 Compound 34 | 6-cyanouridine 5-monophosp...)
Affinity DataKi:  2.60E+4nM ΔG°:  -27.2kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21335(JMC521648 Compound 34 | 6-cyanouridine 5-monophosp...)
Affinity DataKi:  2.90E+4nM ΔG°:  -28.5kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(malaria parasite P. falciparum)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  3.41E+4nM ΔG°:  -26.5kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine-5'-phosphate decarboxylase(Plasmodium vivax)
Toronto General Research Institute

LigandPNGBDBM21335(JMC521648 Compound 34 | 6-cyanouridine 5-monophosp...)
Affinity DataKi:  6.20E+4nMpH: 7.5Assay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM21339(6-Methyl-uridine 5-O-Monophosphate | JMC521648 Com...)
Affinity DataKi:  1.34E+5nM ΔG°:  -24.3kJ/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)