Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with all data for entry = 50022114
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231695(N-((2S,3R)-4-(4-methoxybenzylamino)-3-hydroxy-1-ph...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231676(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-(3-methox...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231694(N-((2S,3R)-4-(3-(trifluoromethoxy)benzylamino)-3-h...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231688(N-((2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydr...)
Affinity DataIC50: 33nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231698(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(6-methylhep...)
Affinity DataIC50: 33nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231680(N-((2S,3R)-4-(3-methoxybenzylamino)-3-hydroxy-1-ph...)
Affinity DataIC50: 43nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231689(N-((2S,3R)-4-(3-chlorobenzylamino)-3-hydroxy-1-phe...)
Affinity DataIC50: 83nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231686(N-((2S,3R)-4-(3,5-dimethoxybenzylamino)-3-hydroxy-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231690(TCMDC-138917 | N-((2S,3R)-4-((S)-2,3-dihydro-1H-in...)
Affinity DataIC50: 160nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231678(N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 200nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231688(N-((2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydr...)
Affinity DataIC50: 210nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231673(N-((2S,3R)-4-((1-ethyl-1H-pyrazol-4-yl)methylamino...)
Affinity DataIC50: 230nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231688(N-((2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydr...)
Affinity DataIC50: 230nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231684(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(5-methylhex...)
Affinity DataIC50: 305nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231677(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-((6-methoxyp...)
Affinity DataIC50: 330nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231676(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-(3-methox...)
Affinity DataIC50: 370nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231676(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-(3-methox...)
Affinity DataIC50: 380nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231687(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(2-methylhep...)
Affinity DataIC50: 550nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50: 600nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231679(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(te...)
Affinity DataIC50: 650nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231699(N-((2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 760nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231678(N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 780nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231683(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-isobutoxy...)
Affinity DataIC50: 790nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50: 930nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231684(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(5-methylhex...)
Affinity DataIC50: 970nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231698(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(6-methylhep...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231674(N-((2S,3R)-4-(cycloheptylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231693(N-((2S,3R)-4-(2-methoxybenzylamino)-3-hydroxy-1-ph...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231679(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(te...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231681(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(ph...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231694(N-((2S,3R)-4-(3-(trifluoromethoxy)benzylamino)-3-h...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231695(N-((2S,3R)-4-(4-methoxybenzylamino)-3-hydroxy-1-ph...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231674(N-((2S,3R)-4-(cycloheptylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231675(N-((2S,3R)-4-(cyclopentylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231688(N-((2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydr...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231698(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(6-methylhep...)
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231694(N-((2S,3R)-4-(3-(trifluoromethoxy)benzylamino)-3-h...)
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231684(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(5-methylhex...)
Affinity DataIC50: 3.61E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
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