Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2911
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50: 59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nM ΔG°:  -37.4kJ/mole IC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi:  400nM ΔG°:  -36.2kJ/mole IC50: 2.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | N-(cyclopropylmethyl)-4-[2...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole IC50: 3.00E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25979(N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25979(N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/mole IC50: 8.40E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25979(N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | N-(cyclopropylmethyl)-4-[2...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: 1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | N-(cyclopropylmethyl)-4-[2...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: 1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed