Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 2315
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19263([({[(2R,3S,4R,5R)-5-(6-amino-2-ethyl-9H-purin-9-yl...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19257({[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19261([({[(2R,3S,4R,5R)-5-(6-amino-2-ethynyl-9H-purin-9-...)
Affinity DataKi:  10nM ΔG°:  -45.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19263([({[(2R,3S,4R,5R)-5-(6-amino-2-ethyl-9H-purin-9-yl...)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19267([({[(2R,3S,4R,5R)-5-(6-amino-2-ethyl-9H-purin-9-yl...)
Affinity DataKi:  16nM ΔG°:  -44.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19255([({[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)...)
Affinity DataKi:  19nM ΔG°:  -44.1kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19256([({[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-y...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19257({[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3...)
Affinity DataKi:  27nM ΔG°:  -43.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  33nM ΔG°:  -42.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19267([({[(2R,3S,4R,5R)-5-(6-amino-2-ethyl-9H-purin-9-yl...)
Affinity DataKi:  38nM ΔG°:  -42.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19258([({[(2R,3S,4R,5R)-5-[6-amino-2-(phenylamino)-9H-pu...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19259([({[(2R,3S,4R,5R)-5-[6-amino-2-(benzylamino)-9H-pu...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19261([({[(2R,3S,4R,5R)-5-(6-amino-2-ethynyl-9H-purin-9-...)
Affinity DataKi:  49nM ΔG°:  -41.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19266([({[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-y...)
Affinity DataKi:  66nM ΔG°:  -41.0kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19260([({[(2R,3S,4R,5R)-5-{6-amino-2-[(2-phenylethyl)ami...)
Affinity DataKi:  73nM ΔG°:  -40.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19255([({[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)...)
Affinity DataKi:  84nM ΔG°:  -40.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19262([({[(2R,3S,4R,5R)-5-(6-amino-2-ethenyl-9H-purin-9-...)
Affinity DataKi:  94nM ΔG°:  -40.1kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19262([({[(2R,3S,4R,5R)-5-(6-amino-2-ethenyl-9H-purin-9-...)
Affinity DataKi:  96nM ΔG°:  -40.1kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19266([({[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-y...)
Affinity DataKi:  108nM ΔG°:  -39.8kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19253(CHEMBL394276 | NSC 358285 | [(2R,3S,4R,5R)-5-(6-am...)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19253(CHEMBL394276 | NSC 358285 | [(2R,3S,4R,5R)-5-(6-am...)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19256([({[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-y...)
Affinity DataKi:  143nM ΔG°:  -39.1kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19258([({[(2R,3S,4R,5R)-5-[6-amino-2-(phenylamino)-9H-pu...)
Affinity DataKi:  153nM ΔG°:  -38.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19259([({[(2R,3S,4R,5R)-5-[6-amino-2-(benzylamino)-9H-pu...)
Affinity DataKi:  169nM ΔG°:  -38.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19265([({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKi:  250nM ΔG°:  -37.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19260([({[(2R,3S,4R,5R)-5-{6-amino-2-[(2-phenylethyl)ami...)
Affinity DataKi:  255nM ΔG°:  -37.6kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Human)
University of Minnesota At Twin Citiies

LigandPNGBDBM19265([({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKi:  330nM ΔG°:  -37.0kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMed