Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50021444
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 42nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 198nMAssay Description:Inhibition of recombinant aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 227nMAssay Description:Inhibition of recombinant aurora C kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224749(4-(6,7-dichloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N...)
Affinity DataIC50: 250nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224745(4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dime...)
Affinity DataIC50: 490nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224731(4-(6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dim...)
Affinity DataIC50: 570nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224750(N,N-dimethyl-4-(6-(trifluoromethyl)-3H-imidazo[4,5...)
Affinity DataIC50: 740nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224742(2-(4-(2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b...)
Affinity DataIC50: 870nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224738(4-(7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dim...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224740(4-(3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethylbenz...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224751(2-(4-(piperidin-2-yl)phenyl)-3H-imidazo[4,5-b]pyri...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224736(2-(4-(pyrrolidin-1-yl)phenyl)-3H-imidazo[4,5-b]pyr...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224754(2-(4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224752(2-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridine | 2-...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224737(N,N-dimethyl-4-(6-methyl-3H-imidazo[4,5-b]pyridin-...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224733(N,N-dimethyl-4-(7-methyl-3H-imidazo[4,5-b]pyridin-...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224753(1-(3-(2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224748(6,7-dimethoxy-4-(4-(naphthalen-1-ylmethyl)piperazi...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224758(3-(3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethylbenz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2A6 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224734(2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224739(4-(3H-imidazo[4,5-c]pyridin-2-yl)-N,N-dimethylbenz...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224743(2-(3-methoxyphenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224746(2-(4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)...)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224756(3-(2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]py...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224757(4-(6-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224741(6,7-dimethoxy-4-(4-(1-phenylethyl)piperazin-1-yl)q...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50045027(CHEMBL543042 | CHEMBL236937 | 2-(2-Methoxy-phenyl)...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224755(6,7-dimethoxy-4-(4-(2-phenoxyethyl)piperazin-1-yl)...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224732(4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxy...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224747(6,7-dimethoxy-4-(4-phenethylpiperazin-1-yl)quinazo...)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224744(2-(4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed