Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50021427
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224426(N-{(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-[2-(trif...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224412(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(pyridin...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224430(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylsulf...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224419(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-methoxyethy...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224422(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylthio...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224421(N-[(3R,6S)-1-(cyclopropylmethyl)-6-(2,3-difluoroph...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224431(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-t...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224413(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-morpholin-4...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224430(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylsulf...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224419(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-methoxyethy...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224413(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-morpholin-4...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224415(N-[(3R,6S)-1-(2,2-difluoroethyl)-6-(2,3-difluoroph...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224417(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-fluoroethyl...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224420(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylsulf...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224432(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-ethyl-2-oxoaze...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224426(N-{(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-[2-(trif...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224422(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylthio...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224420(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylsulf...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224418(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(dimethylam...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224411(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-methyl-2-oxoaz...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224417(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-fluoroethyl...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224412(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(pyridin...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224431(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-t...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224424(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224415(N-[(3R,6S)-1-(2,2-difluoroethyl)-6-(2,3-difluoroph...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224410(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxyethy...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224418(N-{(3R,6S)-6-(2,3-difluorophenyl)-1-[2-(dimethylam...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224421(N-[(3R,6S)-1-(cyclopropylmethyl)-6-(2,3-difluoroph...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224411(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-methyl-2-oxoaz...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224424(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224410(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxyethy...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224432(N-[(3R,6S)-6-(2,3-difluorophenyl)-1-ethyl-2-oxoaze...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224436(N-[(3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224423(N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224423(N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224425(N-[(3R)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-(2-...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224434(N-[(3R,6S)-6-(3-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224434(N-[(3R,6S)-6-(3-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224425(N-[(3R)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-(2-...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224436(N-[(3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 340nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224435(N-[(3R)-6-(3-fluorophenyl)-2-oxoazepan-3-yl]-4-(2-...)
Affinity DataIC50: 340nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224428(N-[(3R)-6-isopropyl-2-oxoazepan-3-yl]-4-(2-oxo-2,3...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224414(4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224428(N-[(3R)-6-isopropyl-2-oxoazepan-3-yl]-4-(2-oxo-2,3...)
Affinity DataIC50: 620nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224414(4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224437(4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl...)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224427(N-[(3R)-6-benzyl-2-oxoazepan-3-yl]-4-(2-oxo-2,3-di...)
Affinity DataIC50: 920nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224429(N-[(3R)-6-(4-hydroxyphenyl)-2-oxoazepan-3-yl]-4-(2...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224437(4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224426(N-{(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-[2-(trif...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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