Compile Data Set for Download or QSAR
Report error Found 56 Enz. Inhib. hit(s) with all data for entry = 50021402
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 11-beta-HSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224212(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 11-beta-HSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11-beta-HSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224208(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224216(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224205(2-(2,6-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224217(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224212(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224203(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224222(2-(2,4-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224202(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224200(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224211(5-isopropyl-2-(isoquinolin-5-ylamino)thiazol-4(5H)...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224201(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224206(5-isopropyl-2-(phenylamino)thiazol-4(5H)-one | CHE...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224215(2-(1H-indol-4-ylamino)-5-isopropylthiazol-4(5H)-on...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataIC50: 380nMAssay Description:Inhibition of human 11-beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224202(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human 11-beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224204(5-isopropyl-2-(pyridin-2-ylamino)thiazol-4(5H)-one...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224214(2-(1H-indazol-5-ylamino)-5-isopropylthiazol-4(5H)-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224209(5-isopropyl-2-(2-methoxyphenylamino)thiazol-4(5H)-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224208(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human 11-beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224210(2-(4-cyclohexylphenylamino)-5-isopropylthiazol-4(5...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human 11-beta-HSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224216(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human 11-beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224203(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human 11-beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224216(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataKi:  7nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224208(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224202(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224203(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
Affinity DataKi:  11nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224217(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataKi:  12nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224205(2-(2,6-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataKi:  13nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataKi:  17nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224222(2-(2,4-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataKi:  18nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224212(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Affinity DataKi:  23nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224200(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Affinity DataKi:  26nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataKi:  27nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224211(5-isopropyl-2-(isoquinolin-5-ylamino)thiazol-4(5H)...)
Affinity DataKi:  32nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224206(5-isopropyl-2-(phenylamino)thiazol-4(5H)-one | CHE...)
Affinity DataKi:  110nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224207(CHEMBL396617 | CHEMBL392452 | CHEMBL393908 | 2-(2-...)
Affinity DataKi:  140nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224215(2-(1H-indol-4-ylamino)-5-isopropylthiazol-4(5H)-on...)
Affinity DataKi:  210nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224223(5-isopropyl-2-(4-phenoxyphenylamino)thiazol-4(5H)-...)
Affinity DataKi:  220nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224201(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataKi:  340nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224220(2-(2-chlorophenylamino)-5-methylthiazol-4(5H)-one ...)
Affinity DataKi:  350nMAssay Description:Inhibition of human 11-beta-HSD1 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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