Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50038917
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 10nMAssay Description:Inhibition of CAMKKbeta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Aurora C in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 19nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Aurora B in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50095227((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Affinity DataIC50: 26nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50169959([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PIM3 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2-cyclinA in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50: 31nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4811((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Aurora B in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 36nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Aurora B in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50169959([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of GSK3-beta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 41nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 53nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 70nMAssay Description:Inhibition of PIM2 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Aurora C in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50169959([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of PIM1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM100152(cid_5359389 | SMR001233259 | HARMINE | 7-methoxy-1...)
Affinity DataIC50: 80nMAssay Description:Inhibition of DYRK1A in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 83nMAssay Description:Inhibition of PIM3 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 100nMAssay Description:Inhibition of BRSK2 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 100nMAssay Description:Inhibition of PIM3 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 110nMAssay Description:Inhibition of PIM2 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 110nMAssay Description:Inhibition of MST2 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 120nMAssay Description:Inhibition of CAMKKalpha in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 120nMAssay Description:Inhibition of MNK1 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50229961(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)
Affinity DataIC50: 120nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US9765037,...)
Affinity DataIC50: 130nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of PAK4 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US9765037,...)
Affinity DataIC50: 140nMAssay Description:Inhibition of JNK-M108G in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2-cyclinA in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50229961(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 170nMAssay Description:Inhibition of PIM1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 170nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50095227((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 190nMAssay Description:Inhibition of B-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4811((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)
Affinity DataIC50: 210nMAssay Description:Inhibition of Aurora C in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50: 230nMAssay Description:Inhibition of B-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US9765037,...)
Affinity DataIC50: 250nMAssay Description:Inhibition of PKD1 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US9765037,...)
Affinity DataIC50: 250nMAssay Description:Inhibition of JNK-M108A in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50130248(PS-1145 | N-(6-Chloro-9H-beta-carbolin-8-yl)-nicot...)
Affinity DataIC50: 250nMAssay Description:Inhibition of IKK-beta in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50229961(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)
Affinity DataIC50: 270nMAssay Description:Inhibition of JNK-M108A in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50229971(4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CK1delta in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50169959([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of DYRK2 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 340nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
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