Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50021051
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 0.0200nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220379(3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile |...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220389(2'-chloro-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 9.80nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220379(3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile |...)
Affinity DataIC50: 10.9nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 11.9nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220384(2',6'-dimethoxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50: 14.7nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 20.1nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 37nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 39.9nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 56.7nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 61.2nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220375(2'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 146nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220382(4'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 200nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220380(3'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 229nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220384(2',6'-dimethoxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50: 399nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220382(4'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 843nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 955nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220377(2',6'-dihydroxy-3-trifluoromethyl-biphenyl-4-carbo...)
Affinity DataIC50: 989nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220375(2'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220381((4'-cyano-3'-trifluoromethyl-biphenyl-2-yloxy)-ace...)
Affinity DataIC50: 1.31E+3nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220387(2'-(2-hydroxy-ethoxy)-3-trifluoromethyl-biphenyl-4...)
Affinity DataIC50: 1.54E+3nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220386(3'-methyl-3-trifluoromethyl-biphenyl-4-carbonitril...)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220391(2'-(2-methoxy-ethoxy)-3-trifluoromethyl-biphenyl-4...)
Affinity DataIC50: 2.23E+3nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220376(2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 3.25E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 4.45E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220383(4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 5.52E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220390(2'-[2-(2-methoxy-ethoxy)-ethoxy]-3-trifluoromethyl...)
Affinity DataIC50: 8.14E+3nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220388(3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 9.46E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220378((4'-cyano-3'-trifluoromethyl-biphenyl-2-yloxy)-ace...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220385(4'-hydroxy-3-trifluoromethyl-biphenyl-4-carbonitri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed