Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 2552
LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21915(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(py...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21928(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[4...)
Affinity DataIC50: 16nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21930(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4...)
Affinity DataIC50: 16nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21920(2-[({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21925(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21897(4-[(3-chloro-4-fluorophenyl)amino]-8-fluoro-6-[(1H...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21896(BMCL193485 Compound 2 | CHEMBL220037 | 4-[(3-chlor...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21926(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50: 20nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21903(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21906(4-[(3-chloro-4-fluorophenyl)amino]-8-acetyl-6-[(1H...)
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21929(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4...)
Affinity DataIC50: 25nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21933(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 30nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21896(BMCL193485 Compound 2 | CHEMBL220037 | 4-[(3-chlor...)
Affinity DataIC50: 30nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21938(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50: 41nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21939(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-...)
Affinity DataIC50: 43nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21931(methyl 5-[({8-bromo-4-[(3-chloro-4-fluorophenyl)am...)
Affinity DataIC50: 87nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21912(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 98nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21924(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50: 110nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21932(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({4...)
Affinity DataIC50: 130nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21905(4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-[(1H-...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21927(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[4-...)
Affinity DataIC50: 130nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21909(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[2-...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21906(4-[(3-chloro-4-fluorophenyl)amino]-8-acetyl-6-[(1H...)
Affinity DataIC50: 156nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21900(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 160nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21918(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(6...)
Affinity DataIC50: 170nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21904(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 190nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21923(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50: 200nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21935(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2...)
Affinity DataIC50: 220nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21936(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1...)
Affinity DataIC50: 220nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21913(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 250nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21914(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({im...)
Affinity DataIC50: 280nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21911(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1...)
Affinity DataIC50: 290nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21934(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2...)
Affinity DataIC50: 320nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21919(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[6...)
Affinity DataIC50: 350nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21917(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({5...)
Affinity DataIC50: 500nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21897(4-[(3-chloro-4-fluorophenyl)amino]-8-fluoro-6-[(1H...)
Affinity DataIC50: 500nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21921(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2,3...)
Affinity DataIC50: 590nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21908(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50: 830nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21907(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50: 910nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50: 1.80E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 2.08E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21920(2-[({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3...)
Affinity DataIC50: 2.90E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21916(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[5...)
Affinity DataIC50: 3.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 3.30E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandPNGBDBM21903(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 5.00E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandPNGBDBM21910(N-{8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-3-cy...)
Affinity DataIC50: 5.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
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