Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50020683
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216434(dimethyl-(tetrahydro-pyran-4-yl)-{4-[(E)-3-(4'-tri...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216453(dimethyl-{4-[(E)-3-(4'-methyl-biphenyl-4-yl)-acryl...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216442(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethylcy...)
Affinity DataIC50: 30nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216445(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethylcy...)
Affinity DataIC50: 40nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216431(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethylbi...)
Affinity DataIC50: 90nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at CCR2 receptor in PBMC assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at CCR2 receptor in THP1 cells assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216432(N-(4-(7-chloro-2H-chromene-3-carboxamido)benzyl)-N...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216447(N-(4-(7-methyl-2H-chromene-3-carboxamido)benzyl)-N...)
Affinity DataIC50: 170nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216446(N-(4-(7-bromo-2H-chromene-3-carboxamido)benzyl)-N,...)
Affinity DataIC50: 180nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216444(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216455(N-(4-(3-chlorobenzamido)benzyl)-N,N-dimethyl-tetra...)
Affinity DataIC50: 230nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216448(N-(4-(3-bromobenzamido)benzyl)-N,N-dimethyl-tetrah...)
Affinity DataIC50: 250nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216454(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethylcy...)
Affinity DataIC50: 290nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216452(N-(4-(3-chloro-4-fluorobenzamido)benzyl)-N,N-dimet...)
Affinity DataIC50: 390nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216438(N-(4-(3,5-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 710nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of MIP1-alpha from CCR5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216428(N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl(t...)
Affinity DataIC50: 1.02E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216449(N-(4-(3-(3-fluorophenyl)acrylamido)benzyl)-N,N-dim...)
Affinity DataIC50: 1.81E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216429(N-(4-(4-chlorobenzamido)benzyl)-N,N-dimethyl-tetra...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216437(N-(4-(3-(trifluoromethyl)benzamido)benzyl)-N,N-dim...)
Affinity DataIC50: 2.05E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216427(N-(4-(3-(3,4-dichlorophenyl)acrylamido)benzyl)-N,N...)
Affinity DataIC50: 2.55E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216440(N-(4-(3-cyanobenzamido)benzyl)-N,N-dimethyl-tetrah...)
Affinity DataIC50: 3.25E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216451(dimethyl-{4-[(4'-methyl-biphenyl-3-carbonyl)-amino...)
Affinity DataIC50: 3.44E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216430(N-(4-(3-methylbenzamido)benzyl)-N,N-dimethyl-tetra...)
Affinity DataIC50: 4.25E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216441(N-(4-benzamidobenzyl)-N,N-dimethyl-tetrahydro-2H-p...)
Affinity DataIC50: 4.75E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216439(N-(4-(2,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 7.80E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216436(N-(4-((3,4-dichlorobenzamido)methyl)benzyl)-N,N-di...)
Affinity DataIC50: 8.95E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216450(N-(4-(3-methoxybenzamido)benzyl)-N,N-dimethyl-tetr...)
Affinity DataIC50: 9.55E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216443(N-(4-(2-chlorobenzamido)benzyl)-N,N-dimethyl-tetra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216433(N-(4-(3,4-dichlorobenzamido)phenethyl)-N,N-dimethy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216426(N-(4-(2,3-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216425(N-(3-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-t...)
Affinity DataIC50: 1.14E+4nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed