Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50020606
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215452(3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine ...)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215448(5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine ...)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215451(3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine |...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215457(3-(2-(5-methyl-1,2,4-triazin-3-yl)ethynyl)benzonit...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215460(5-methyl-3-(2-(4-phenoxyphenyl)ethynyl)-1,2,4-tria...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215449(5-methyl-3-(2-(3-(trifluoromethyl)phenyl)ethynyl)-...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215456(3-(2-(3-fluorophenyl)ethynyl)-5-methyl-1,2,4-triaz...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215459(3-(2-(4-fluoro-3-methylphenyl)ethynyl)-5-methyl-1,...)
Affinity DataIC50: 132nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215455(5-methyl-3-phenylethynyl[1,2,4]triazine | CHEMBL22...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215450(3-(2-(3-methoxyphenyl)ethynyl)-5-methyl-1,2,4-tria...)
Affinity DataIC50: 312nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215458(3-biphenyl-4-ylethynyl-5-methyl-[1,2,4]triazine | ...)
Affinity DataIC50: 510nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215453(3-(2-(2,5-dimethylphenyl)ethynyl)-5-methyl-1,2,4-t...)
Affinity DataIC50: 1.89E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50215454(5-methyl-3-(2-(naphthalen-1-yl)ethynyl)-1,2,4-tria...)
Affinity DataIC50: 8.90E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHOK1 cells assessed as inhibition of glutamate-mediated internal calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed