Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50020286
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212194(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212180(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212174(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212196((5R,14R)-5-amino-19-[(dimethylsulfamoyl)(methyl)am...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212180(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1-mediated sAPP-NF processing in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212197(N-[(5R,14R)-5-amino-14-(4-fluoro-phenyl)-5-methyl-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212193(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212183(2,2,2-trifluoro-ethanesulfonic acid ((5R,14R)-5-am...)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212178(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212192(2-[(5R,14R)-5-amino-14-(4-fluoro-phenyl)-5-methyl-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212178(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 23nMAssay Description:Inhibition of BACE1-mediated sAPP-NF processing in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212189(2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212195(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212190(2-[(5R,14R)-5-amino-10-fluoro-14-(4-fluoro-phenyl)...)
Affinity DataIC50: 46nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212175(2-[(5R,14R)-5-amino-10-fluoro-14-(4-fluoro-phenyl)...)
Affinity DataIC50: 46nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212186(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 49nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212185(N-((5R,14R)-5-amino-14-ethynyl-5-methyl-16-oxo-3-o...)
Affinity DataIC50: 53nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212188(ethanesulfonic acid ((5R,14R)-5-amino-5-methyl-16-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212189(2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 68nMAssay Description:Inhibition of BACE1-mediated sAPP-NF processing in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212198(2-[(5R,14R)-5-amino-22-fluoro-14-(4-fluoro-phenyl)...)
Affinity DataIC50: 78nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212187(N-((5R,14S)-5-amino-14-ethyl-5-methyl-16-oxo-3-oxa...)
Affinity DataIC50: 85nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212182(2-[(5R,14R)-5-amino-9-fluoro-14-(4-fluoro-phenyl)-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212191(N-((5R,14R)-5-amino-14-isopropyl-5-methyl-16-oxo-3...)
Affinity DataIC50: 175nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212184(propane-2-sulfonic acid ((5R,14R)-5-amino-5-methyl...)
Affinity DataIC50: 196nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212179((5R,14R)-5-amino-19-bromo-5-methyl-14-phenyl-3-oxa...)
Affinity DataIC50: 270nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212176(N-((5R,14S)-5-amino-5,14-dimethyl-16-oxo-3-oxa-15-...)
Affinity DataIC50: 290nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212177((5R,14R)-5-amino-5-methyl-19-oxazol-2-yl-14-phenyl...)
Affinity DataIC50: 780nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212181(N-((5R,14R)-5-amino-14-cyclopropyl-5-methyl-16-oxo...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212178(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212189(2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212189(2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212180(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212180(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212178(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 1.44E+5nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212180(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212189(2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 2.75E+5nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212178(N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-ox...)
Affinity DataIC50: 2.75E+5nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed