Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 2312
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19217BDBM19217((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 5.10nM EC50:  1nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19224BDBM19224(CHEMBL372684 | (S)-[(4aR,5S)-1-(4-fluorophenyl)-4a...)
Affinity DataIC50: 1.5nM EC50:  6nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19219BDBM19219((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 28nM EC50:  2.10nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19225BDBM19225((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 2.10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19231BDBM19231((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 2.30nM EC50:  3nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19226BDBM19226((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 3.10nM EC50:  10nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19232BDBM19232((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 3.90nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19190BDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 13.8nM EC50:  4.5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19229BDBM19229((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 5nM EC50:  48nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19223BDBM19223((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 5.10nM EC50:  18nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19192BDBM19192(BMCL173354 benzo[f]indazole, 6 | (R)-[(4aR,5S)-1-(...)
Affinity DataIC50: 5.30nM EC50:  9.70nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19216BDBM19216((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 12nM EC50:  6nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19230BDBM19230((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 6.40nM EC50:  33nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19218BDBM19218((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 8nM EC50:  21nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19200BDBM19200(BMCL173354 benzo[f]indazole, 7 | (S)-[(4aR,5S)-1-(...)
Affinity DataIC50: 10.4nM EC50:  16.5nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19215BDBM19215((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 17.4nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19220BDBM19220((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 29.1nM EC50:  19nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19221BDBM19221((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 69.1nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19227BDBM19227((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 86nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19228BDBM19228((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 198nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 19222BDBM19222((S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 689nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed