Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50019839
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208225((E)-2-(3-chlorostyrylamino)-1-(5-chlorobenzo[b]thi...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208236(1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208243((E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208232(1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208244((E)-2-(4-fluorostyrylamino)-1-(5-chloro-1-methyl-1...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208222((E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobe...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208229((E)-2-(3,4-difluorostyrylamino)-1-(5-chloro-1-meth...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208228(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208241((E)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxo-2-(sty...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208242((E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208226((E)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxo-2-(sty...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208239((E)-2-(4-fluorostyrylamino)-1-(5-chlorobenzo[b]thi...)
Affinity DataIC50: 66nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208221(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208227(1-(1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208234(1-(benzo[b]thiophen-3-yl)-2-(naphthalen-2-ylamino)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208223(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208235((E)-2-(3,4-difluorostyrylamino)-1-(5-chlorobenzo[b...)
Affinity DataIC50: 165nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208237(1-(naphthalen-1-yl)-2-(naphthalen-2-ylamino)-2-oxo...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208238(methyl(1-(naphthalen-1-yl)-2-(naphthalen-2-ylamino...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208220(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208219((E)-2-(4-methoxystyrylamino)-1-(5-chlorobenzo[b]th...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208231(1-(1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoet...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208240(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208233(1-(benzofuran-3-yl)-2-(naphthalen-2-ylamino)-2-oxo...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208230(2-(3,4-difluorophenethylamino)-1-(5-chlorobenzo[b]...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208222((E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobe...)
Affinity DataKi:  11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208228(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataKi:  36nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin G(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  38nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin G(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208228(1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed