Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 1982
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14320(CHEMBL62083 | 1-amino-isoquinoline | fragment 1 (J...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15788(4-[(4-fluorophenyl)methyl]piperidine | CHEMBL12043...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15781(3-N-benzylpyridine-2,3-diamine | fragment 3 (J. me...)
Affinity DataIC50: 3.10E+5nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15789((2S)-1-(2,5-dimethylphenoxy)-3-(morpholin-4-yl)pro...)
Affinity DataIC50: 1.00E+6nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMed