Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1983
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15797(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 5nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50: 20nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15790(CHEMBL42908 | Hydroxyethylene-Based Peptidomimetic...)
Affinity DataIC50: 30nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15794(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 70nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15792(N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1...)
Affinity DataIC50: 130nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15796((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(ben...)
Affinity DataIC50: 130nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15795(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-({...)
Affinity DataIC50: 200nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15793(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 500nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15791(N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1...)
Affinity DataIC50: 6.80E+4nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed