Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 1732
LigandPNGBDBM13746(2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13749((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13748(2-((S)-1-(2-bromophenyl)ethylamino)-5-isopropyl-5-...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13747(2-((S)-1-(2-chlorophenyl)ethylamino)-5-isopropyl-5...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13750((5R)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13745(5-methyl-5-(propan-2-yl)-2-{[(1S)-1-[2-(trifluorom...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13751(2- ((S)-1-(2-fluorophenyl)ethylamino)-5-(2-fluorop...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13752(2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13754((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13744(5-methyl-5-(propan-2-yl)-2-{[(1S)-1-[3-(trifluorom...)
Affinity DataKi:  45nM ΔG°:  -41.5kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13753((R)-2-((S)-1-(2-fluorophenyl)ethylamino)-5-methyl-...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13741(5-isopropyl-5-methyl-2-((S)-1-phenylethylamino)thi...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13740(2-(benzylamino)-5-methyl-5-(propan-2-yl)-4,5-dihyd...)
Affinity DataKi:  65nM ΔG°:  -40.6kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13743(5-methyl-5-(propan-2-yl)-2-{[(1S)-1-[4-(trifluorom...)
Affinity DataKi:  87nM ΔG°:  -39.9kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13742(5-methyl-2-{[(1R)-1-phenylethyl]amino}-5-(propan-2...)
Affinity DataKi:  130nM ΔG°:  -38.9kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13738(5-methyl-5-(propan-2-yl)-2-{[2-(trifluoromethyl)ph...)
Affinity DataKi:  503nM ΔG°:  -35.6kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed