Compile Data Set for Download or QSAR
Report error Found 84 Enz. Inhib. hit(s) with all data for entry = 50019304
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 23nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 33nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 39nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-N-hydroxy-6-[(4-phenylpiperazin-1-yl)carbo...)
Affinity DataIC50: 52nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 59nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)
Affinity DataIC50: 64nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 68nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)
Affinity DataIC50: 77nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 77nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 92nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 97nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 113nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203529((6S,7S)-N-hydroxy-6-[(4-phenylpiperazin-1-yl)carbo...)
Affinity DataIC50: 120nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203531((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)-3...)
Affinity DataIC50: 130nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203537((6S,7S)-N-hydroxy-6-[(4-phenylpiperidin-1-yl)carbo...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50: 150nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-N-hydroxy-6-[(4-phenylpiperazin-1-yl)carbo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50: 230nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: 280nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203531((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)-3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50: 310nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203537((6S,7S)-N-hydroxy-6-[(4-phenylpiperidin-1-yl)carbo...)
Affinity DataIC50: 320nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: 330nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: 350nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 428nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 450nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203537((6S,7S)-N-hydroxy-6-[(4-phenylpiperidin-1-yl)carbo...)
Affinity DataIC50: 450nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203536((2S,3S)-N-hydroxy-2-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 480nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203536((2S,3S)-N-hydroxy-2-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 560nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-N-hydroxy-6-[(4-phenylpiperazin-1-yl)carbo...)
Affinity DataIC50: 650nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50082539(1-(4-Methoxy-benzenesulfonyl)-piperidine-2-carboxy...)
Affinity DataIC50: 670nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203525((6S,7S)-N-hydroxy-6-[(5-methyl-4-phenyl-3,6-dihydr...)
Affinity DataIC50: 720nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 960nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203525((6S,7S)-N-hydroxy-6-[(5-methyl-4-phenyl-3,6-dihydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203532((6S,7S)-5-methyl-5-aza-spiro[2.5]octane-6,7-dicarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203532((6S,7S)-5-methyl-5-aza-spiro[2.5]octane-6,7-dicarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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