Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with all data for entry = 1874
LigandPNGBDBM14768((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Affinity DataKi:  4nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14760(6,7-dimethoxy-4-[(3R)-3-(naphthalen-2-yloxy)pyrrol...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14764((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14766(6,7-dimethoxy-4-[(3R)-3-(quinolin-7-yloxy)pyrrolid...)
Affinity DataKi:  12nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14763((R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  17nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14765(6,7-dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)ox...)
Affinity DataKi:  18nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14762((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  18nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  19nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14755(6,7-dimethoxy-4-{8-[(4-methylpiperazine-1-)sulfony...)
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14756(4-[(3R)-3-[(5-chloropyrimidin-2-yl)oxy]pyrrolidin-...)
Affinity DataKi:  44nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14761(6,7-dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrol...)
Affinity DataKi:  48nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14748(4-[(3R)-3-(4-ethoxyphenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  54nM ΔG°:  -41.1kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14745((R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14761(6,7-dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrol...)
Affinity DataKi:  56nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14751(4-[(3R)-3-(3-ethoxyphenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  61nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  67nM ΔG°:  -40.5kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14752((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Affinity DataKi:  68nM ΔG°:  -40.5kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14757((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Affinity DataKi:  77nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14751(4-[(3R)-3-(3-ethoxyphenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  88nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14751(4-[(3R)-3-(3-ethoxyphenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14743(4-[(3R)-3-(2-chlorophenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14741((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14739(6,7-dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenox...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14743(4-[(3R)-3-(2-chlorophenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14744((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14744((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14741((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14740((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14739(6,7-dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenox...)
Affinity DataKi: <100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14747((R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14764((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Affinity DataKi:  104nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)
Affinity DataKi:  112nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  121nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14757((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Affinity DataKi:  123nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14758(6,7-dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidi...)
Affinity DataKi:  128nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14744((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Affinity DataKi:  130nM ΔG°:  -38.9kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14750(6,7-dimethoxy-4-[(3R)-3-(3-phenylphenoxy)pyrrolidi...)
Affinity DataKi:  136nM ΔG°:  -38.8kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14752((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Affinity DataKi:  141nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  151nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14765(6,7-dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)ox...)
Affinity DataKi:  152nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14748(4-[(3R)-3-(4-ethoxyphenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  161nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14756(4-[(3R)-3-[(5-chloropyrimidin-2-yl)oxy]pyrrolidin-...)
Affinity DataKi:  162nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14749((R)-4-[3-(3-Isopropyl-phenoxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  171nM ΔG°:  -38.2kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14746(6,7-dimethoxy-4-[(3R)-3-[4-(trifluoromethoxy)pheno...)
Affinity DataKi:  185nM ΔG°:  -38.0kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14767((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Affinity DataKi:  196nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14743(4-[(3R)-3-(2-chlorophenoxy)pyrrolidin-1-yl]-6,7-di...)
Affinity DataKi:  198nM ΔG°:  -37.9kJ/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14762((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Affinity DataKi:  199nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
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