Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 2810
TargetSerine/threonine-protein kinase PLK1(African clawed frog)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Purified Plx1 was first incubated with different concentrations of LFM-A13. The substrate, GST-Cdc25 peptide (254-316) and [gamma-32P]ATP were added ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 2.15E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 2.40E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 2.67E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 2.81E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Paradigm Pharmaceuticals

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataKi:  7.20E+3nM ΔG°:  -29.1kJ/mole IC50: 6.10E+4nMpH: 7.0 T: 2°CAssay Description:The mode of human PLK3 inhibition by LFM-A13 was examined in titration experiments using increasing concentrations of [gamma-32P]ATP and purified N-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2008
Entry Details Article
PubMed