Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 2090
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 110nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: 160nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: 240nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 340nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: 600nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: 3.20E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: 3.50E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: 3.70E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 5.90E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: 8.20E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: 1.29E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: 1.94E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: 3.02E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: 6.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed