Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 2087
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16722(N-(2-methylpropyl)-N2-{[(4S)-17-[(methylsulfonyl)(...)
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16693(5-Substituted isophthalamide, 2 | 1-N-[(1R)-1-(4-f...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16034(N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxy...)
Affinity DataIC50: 15nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16719(1:1 mixture of diastereomers at the tyrosinyl cent...)
Affinity DataIC50: 32nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16721((2S)-2-({[17-(N-methylmethanesulfonamido)-2-oxo-3-...)
Affinity DataIC50: 90nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16720((2S)-2-[({18-[methyl(methylsulfonyl)amino]-2-oxo-3...)
Affinity DataIC50: 1.10E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16718(N-[4-(hydroxymethyl)-2,15-dioxo-11-oxa-3,14-diazat...)
Affinity DataIC50: 2.90E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16717(1-N-[1-hydroxy-3-(3-methoxyphenyl)propan-2-yl]-3-N...)
Affinity DataIC50: 1.00E+5nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed