Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2246
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18530(6-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  4.40nM ΔG°:  -49.6kJ/mole EC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18534(6-[bis(cyclopropylmethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  6.30nM ΔG°:  -48.7kJ/mole EC50:  1.90nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18535(6-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Affinity DataKi:  7.10nM ΔG°:  -48.4kJ/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18536(6-[(cyclopropylmethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  7.10nM ΔG°:  -48.4kJ/mole EC50:  2.80nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18533(6-[ethyl(propan-2-yl)amino]-4-(trifluoromethyl)-1,...)
Affinity DataKi:  7.40nM ΔG°:  -48.3kJ/mole EC50:  2.20nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18527(6-(propylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  54nM ΔG°:  -43.2kJ/mole IC50: 27.5nM EC50:  2.02E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18528(6-(propan-2-ylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/mole IC50: 16.5nM EC50:  106nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18531(6-(dipropylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Affinity DataKi:  64nM ΔG°:  -42.7kJ/mole EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18529(6-(dimethylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Affinity DataKi:  153nM ΔG°:  -40.5kJ/mole IC50: 34nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18532(6-(dibutylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  222nM ΔG°:  -39.5kJ/mole IC50: 29.5nM EC50:  1.28E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18526(6-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.7kJ/mole IC50: 26nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed