Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50037817
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194591(3-methoxy-N',N',2-triphenylquinoline-4-carbohydraz...)
Affinity DataIC50: 0.850nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194588(N'-(8-fluoro-3-methoxy-2-phenyl-quinoline-4-carbon...)
Affinity DataIC50: 4.10nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 4.5nMAssay Description:Binding affinity to gerbil NK3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194558(CHEMBL373569 | ELEDOISIN)
Affinity DataEC50:  5.70nMAssay Description:Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194577(N-(3-fluoro-phenyl)-N'-(3-methoxy-2-phenyl-quinoli...)
Affinity DataIC50: 7.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194585(N'-(3-methyl-2-phenyl-quinoline-4-carbonyl)-N-phen...)
Affinity DataIC50: 8.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 8.80nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194587(N'-(3-amino-2-phenyl-quinoline-4-carbonyl)-N-pheny...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194582(N'-(5-fluoro-3-methoxy-2-phenyl-quinoline-4-carbon...)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194576(N'-ethyl-3-methoxy-N',2-diphenylquinoline-4-carboh...)
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194598(N'-[2-(3-fluoro-phenyl)-3-methoxy-quinoline-4-carb...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194579(3-methoxy-N',2-diphenyl-N'-propionylquinoline-4-ca...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194592(N'-[2-(4-fluoro-phenyl)-3-methoxy-quinoline-4-carb...)
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 28nMAssay Description:Activity at human NK3 receptor assessed as inhibition of senktide-stimulated inositol phosphate generation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194590(N'-(7-fluoro-3-methoxy-2-phenyl-quinoline-4-carbon...)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 30nMAssay Description:Activity at human NK3 receptor assessed as inhibition of senktide-induced calcium mobilization in CHO cells at 2.8 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194593(3-methoxy-N',2-diphenylquinoline-4-carbohydrazide ...)
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194584(N-(4-fluoro-phenyl)-N'-(3-methoxy-2-phenyl-quinoli...)
Affinity DataIC50: 33nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194580(N'-(6-fluoro-3-methoxy-2-phenyl-quinoline-4-carbon...)
Affinity DataIC50: 38nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194578(N'-(3-hydroxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 39nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194595(N-(2-fluoro-phenyl)-N'-(3-methoxy-2-phenyl-quinoli...)
Affinity DataIC50: 53nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194596(3-methoxy-N'-methyl-N',2-diphenylquinoline-4-carbo...)
Affinity DataIC50: 57nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194597(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 60nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 66nMAssay Description:Binding affinity to rat NK3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194599(N-phenyl-N'-(2-phenyl-quinoline-4-carbonyl)-hydraz...)
Affinity DataIC50: 91nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194583(N'-[2-(2-fluoro-phenyl)-3-methoxy-quinoline-4-carb...)
Affinity DataIC50: 110nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194589(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 190nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194586(N'-acetyl-3-methoxy-N',2-diphenylquinoline-4-carbo...)
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194594(N'-(8-bromo-3-methoxy-2-phenyl-quinoline-4-carbony...)
Affinity DataIC50: 430nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human NK2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194575(N'-(3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phe...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed