Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 4265
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Gpc Biotech

LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataEC50:  1nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Gpc Biotech

LigandPNGBDBM10890(E7070 | Sulfonamide, 7 | Compound 6 | CHEMBL77517 ...)
Affinity DataIC50: 7nM EC50:  80nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Gpc Biotech

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataIC50: 14nM EC50:  40nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
Gpc Biotech

LigandPNGBDBM59253(RGB-285961)
Affinity DataIC50: 20nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Gpc Biotech

LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataIC50: 28nM EC50: <3nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Gpc Biotech

LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 372nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2011
Entry Details Article
PubMed