Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50018090
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191127(2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine ...)
Affinity DataIC50: 5nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191116(2-(3-(3-chlorophenylthio)prop-1-ynyl)-6-methylpyri...)
Affinity DataIC50: 43nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191124(2-methyl-6-(4-phenylpent-1-ynyl)pyridine | CHEMBL2...)
Affinity DataIC50: 59nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191117(2-methyl-6-(4-phenylbut-1-ynyl)pyridine | CHEMBL21...)
Affinity DataIC50: 78nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191129(2-(3-(3-chlorophenylthio)but-1-ynyl)-6-methylpyrid...)
Affinity DataIC50: 118nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191130(3-chloro-N-(3-(6-methylpyridin-2-yl)prop-2-ynyl)be...)
Affinity DataIC50: 174nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191131(N-(3-(6-methylpyridin-2-yl)prop-2-ynyl)benzenamine...)
Affinity DataIC50: 223nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191123(2-methyl-6-(5-phenylpent-1-ynyl)pyridine | CHEMBL3...)
Affinity DataIC50: 258nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191118(2-(3-(3-chlorophenoxy)but-1-ynyl)-6-methylpyridine...)
Affinity DataIC50: 281nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191113(2-(2-(benzo[b]thiophen-2-yl)ethynyl)-6-methylpyrid...)
Affinity DataIC50: 306nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191119(2-(3-(3-chlorophenylthio)-4-methylpent-1-ynyl)-6-m...)
Affinity DataIC50: 461nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191120(2-methyl-6-(3-(phenylthio)prop-1-ynyl)pyridine | C...)
Affinity DataIC50: 589nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191114(3-chloro-N-(4-(6-methylpyridin-2-yl)but-3-yn-2-yl)...)
Affinity DataIC50: 709nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191122(2-(3-(3-chlorophenylthio)pent-1-ynyl)-6-methylpyri...)
Affinity DataIC50: 862nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191126(3-chloro-N-(3-(6-methylpyridin-2-yl)prop-2-ynyl)be...)
Affinity DataIC50: 2.61E+3nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191125(N-methyl-N-(3-(6-methylpyridin-2-yl)prop-2-ynyl)be...)
Affinity DataIC50: 6.73E+3nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191128(3-(6-methylpyridin-2-yl)-N-phenylpropiolamide | CH...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191121(2-methyl-6-(3-(phenylsulfinyl)prop-1-ynyl)pyridine...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191115(1-(3-chlorophenyl)-3-(3-(6-methylpyridin-2-yl)prop...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed