Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50018053
TargetOxytocin receptor(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 3.70nMAssay Description:Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP450 2C9 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using PPR fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of CYP450 2C9 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of CYP450 2D6 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using PPR fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of CYP450 1A2 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of CYP450 1A2 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP450 2D6 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP450 2C19 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP450 2C19 transfected in human microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed