Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50032216
TargetMitogen-activated protein kinase 14(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM14831(diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...)
Affinity DataKd:  1.16E+3nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50326001(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 18nMAssay Description:Inhibition of VEGFR-3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 22nMAssay Description:Inhibition of B-Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50153859(N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 57nMAssay Description:Inhibition of PDGFRbeta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 58nMAssay Description:Inhibition of Flt3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50326001(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin...)
Affinity DataIC50: 67nMAssay Description:Inhibition of PDGFRalpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 68nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50: 70nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 98nMAssay Description:Inhibition of JNK2alpha2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 188nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13353(3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...)
Affinity DataIC50: 340nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 386nMAssay Description:Inhibition of PDGFRbeta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 413nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 580nMAssay Description:Inhibition of FGFR-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 695nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 800nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50114250(1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-(4-pyr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Syk kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of Fyn kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of Lck kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKi:  37nMAssay Description:Inhibition of unphosphorylated AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of phosphorylated AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed