Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50017820
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187051((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-((3-(dime...)
Affinity DataIC50: 8nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187050((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(3-(dimet...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187046((S)-N-(3,5-bis(trifluoromethyl)benzyl)-5-(dimethyl...)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187047((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to CCR2 in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187043(1'-{2-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]ethyl}-6...)
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 39nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity against CCR2 assessed as inhibition of MCP1-induced calcium flux in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187053((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluoro...)
Affinity DataIC50: 175nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187055(N-(2-((1-(4-chlorobenzyl)piperidin-4-yl)methylamin...)
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187048((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-...)
Affinity DataIC50: 219nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187044(N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(...)
Affinity DataIC50: 342nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187057((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(azepa...)
Affinity DataIC50: 400nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187031((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 424nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187042(N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(...)
Affinity DataIC50: 521nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187056(N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-morpholino...)
Affinity DataIC50: 575nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187049(N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethyla...)
Affinity DataIC50: 592nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187037((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 650nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187040(N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(diethylam...)
Affinity DataIC50: 678nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187054((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-met...)
Affinity DataIC50: 756nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187037((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 770nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187052((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-...)
Affinity DataIC50: 822nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187030((2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(2-me...)
Affinity DataIC50: 838nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187041((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 865nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187045((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimet...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to CCR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to CCR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187035(N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethyla...)
Affinity DataIC50: 1.48E+3nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187033((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piper...)
Affinity DataIC50: 2.00E+3nMAssay Description:Binding affinity to CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187034(4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-N-methyl...)
Affinity DataIC50: 1.34E+4nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187039(1-(3,4-dichlorobenzyl)-5-hydroxy-1H-indole-2-carbo...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-dichlorophenyl)-N-(5-(4-(5-hydroxy-1H-i...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed