Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 1812
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14312(ethyl N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-ind...)
Affinity DataKi:  3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14311(N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-inden-2-y...)
Affinity DataKi:  4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14316((2R)-N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylca...)
Affinity DataKi:  6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14317(N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylcarbamo...)
Affinity DataKi:  21nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14307((2R)-N-[(1S)-1-{[6-amino-1-(1,3-benzothiazol-2-yl)...)
Affinity DataKi:  23nM ΔG°:  -43.2kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14314(prop-2-en-1-yl N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-in...)
Affinity DataKi:  25nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14316((2R)-N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylca...)
Affinity DataKi:  53nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14315(methyl N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-yl...)
Affinity DataKi:  130nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14312(ethyl N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-ind...)
Affinity DataKi:  170nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14313(N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylcarbamo...)
Affinity DataKi:  430nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14311(N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-inden-2-y...)
Affinity DataKi:  530nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14318(N-[(2S)-4-(azetidin-3-yl)-1-(5-{[4-(2,3-dihydro-1H...)
Affinity DataKi:  590nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14297(benzyl N-[(2S)-6-amino-1-(1,3-benzothiazol-2-yl)-1...)
Affinity DataKi:  690nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14314(prop-2-en-1-yl N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-in...)
Affinity DataKi:  1.60E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14300(benzyl N-[(2S,4E)-6-amino-1-(1,3-benzothiazol-2-yl...)
Affinity DataKi:  2.80E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14315(methyl N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-yl...)
Affinity DataKi:  5.70E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14299(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-{...)
Affinity DataKi:  6.90E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14297(benzyl N-[(2S)-6-amino-1-(1,3-benzothiazol-2-yl)-1...)
Affinity DataKi:  7.30E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14317(N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylcarbamo...)
Affinity DataKi:  7.40E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14299(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-{...)
Affinity DataKi:  1.20E+4nM ΔG°:  -27.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14301(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-{...)
Affinity DataKi:  1.30E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14308((2S)-N-[3-(2-amino-1H-1,3-benzodiazol-5-yl)-1-(1,3...)
Affinity DataKi:  1.80E+4nM ΔG°:  -26.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14300(benzyl N-[(2S,4E)-6-amino-1-(1,3-benzothiazol-2-yl...)
Affinity DataKi:  2.50E+4nM ΔG°:  -26.0kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14309(N-[3-(2-amino-1H-1,3-benzodiazol-5-yl)-1-(1,3-benz...)
Affinity DataKi:  3.10E+4nM ΔG°:  -25.5kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14301(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-{...)
Affinity DataKi:  4.50E+4nM ΔG°:  -24.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14313(N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylcarbamo...)
Affinity DataKi:  7.45E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14310(3-(2-amino-1H-1,3-benzodiazol-5-yl)-1-(1,3-benzoth...)
Affinity DataKi:  9.40E+4nM ΔG°:  -22.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM7960(CHEMBL305513 | JMC524454 Compound 5 | 1H-1,3-benzo...)
Affinity DataKi:  1.10E+5nM ΔG°:  -22.4kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14305(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-3-(6-chlo...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14304(benzyl N-[(2S)-3-(3-amino-1H-indazol-5-yl)-1-(1,3-...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14303(benzyl N-[(2S)-3-[(3R)-3-aminopyrrolidin-1-yl]-1-(...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14302(benzyl N-[(2S)-3-(6-aminopyridin-3-yl)-1-(1,3-benz...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14302(benzyl N-[(2S)-3-(6-aminopyridin-3-yl)-1-(1,3-benz...)
Affinity DataKi: >1.50E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14303(benzyl N-[(2S)-3-[(3R)-3-aminopyrrolidin-1-yl]-1-(...)
Affinity DataKi: >1.50E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14304(benzyl N-[(2S)-3-(3-amino-1H-indazol-5-yl)-1-(1,3-...)
Affinity DataKi: >1.50E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14305(benzyl N-[(2S)-1-(1,3-benzothiazol-2-yl)-3-(6-chlo...)
Affinity DataKi: >1.50E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14318(N-[(2S)-4-(azetidin-3-yl)-1-(5-{[4-(2,3-dihydro-1H...)
Affinity DataKi:  1.50E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM7960(CHEMBL305513 | JMC524454 Compound 5 | 1H-1,3-benzo...)
Affinity DataKi:  2.00E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14324(5,6-dimethyl-1H-1,3-benzodiazol-2-amine | Fragment...)
Affinity DataKi:  2.20E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DataKi:  2.20E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14319(1-methyl-1H-1,3-benzodiazol-2-amine | Fragment 16)
Affinity DataKi:  3.70E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14320(CHEMBL62083 | 1-amino-isoquinoline | fragment 1 (J...)
Affinity DataKi:  3.90E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DataKi:  5.60E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14320(CHEMBL62083 | 1-amino-isoquinoline | fragment 1 (J...)
Affinity DataKi:  6.00E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataKi: >2.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14324(5,6-dimethyl-1H-1,3-benzodiazol-2-amine | Fragment...)
Affinity DataKi:  1.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14321(quinolin-4-ol | Fragment 18)
Affinity DataKi: >2.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataKi:  1.20E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14321(quinolin-4-ol | Fragment 18)
Affinity DataKi: >2.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14319(1-methyl-1H-1,3-benzodiazol-2-amine | Fragment 16)
Affinity DataKi:  1.80E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed