Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50017654
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185071((5S,6S,7S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185064((5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185072((5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185063((6S,7S)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.190nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185060((7S,8R)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185062((3R,5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.230nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185073((6S,7S)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185069((5S,6S,7S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.330nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185061((4R,5S,7R)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185068((7S,8R)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.430nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185066((3R,5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.440nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185067((4R,5S,7R)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataIC50: 0.490nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185070((4R,5S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.530nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185065((4R,5S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataIC50: 0.640nMAssay Description:Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185068((7S,8R)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185073((6S,7S)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185062((3R,5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185066((3R,5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185069((5S,6S,7S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi:  6.70E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185061((4R,5S,7R)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi:  8.50E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185072((5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185067((4R,5S,7R)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185060((7S,8R)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185071((5S,6S,7S)-5-((R)-1-(3,5-bis(trifluoromethyl)pheny...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185070((4R,5S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185063((6S,7S)-7-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185065((4R,5S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185064((5S,6S)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi: >9.00E+3nMAssay Description:Displacement of labeled MK-499 from cloned hERG channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed